Density-based screening to identify molecular motors that regulate positioning of different compartments: We have successfully identified kinesins and myosins that control cell organization by siRNA screening based on our density estimation workflow for high-content analysis Duong et al. We are currently validating our hits. Dynamic control of cellular organization using optogenetics: We are employing recently developed optogenetic tools to investigate the function of small GTPases in intracellular organization.
Role of inner cell organization in front-rear cell polarity: A particular case of cell organization is the manifestation of cell polarity. We are studying how organelle positioning regulates the front-rear axis of crossbow-shaped and migrating cells. Uncovering cell morphology changes during cancer progression: Although alterations of cell morphology are a hallmark of cancer, the induced intracellular alterations are still a black box. Karnataka Chitrakala Parishath - Bangalore. Let's Make Puppets!
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